Mir21a^tm1.1Zqy
Targeted Allele Detail

Summary

• Symbol: Mir21a^tm1.1Zqy
• Name: microRNA 21a; targeted mutation 1.1, Zhi-Qiang Yan
• MGI ID: MGI:5514060
• Synonyms: miR21 flox
• Gene: Mir21a Location: Chr11:86474893-86474984 bp, - strand Genetic Position: Chr11, 51.82 cM
• Alliance: Mir21a^tm1.1Zqy page

Decrease in elastin and collagen content in Mir21a^tm1.1Zqy/Mir21a^tm1.1Zqy Tg(Tek-cre)12Flv/0 aorta

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199907
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. (J:199907)

Generation of the Mir21a^tm1.1Zqy allele

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir21a Mutation: 8 strains or lines available

References

• Original: J:199907 Zhang XY, et al., Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. PLoS One. 2013;8(3):e59002
• All: 1 reference(s)