Rgs13^tm1.1Jhk
Targeted Allele Detail

Summary

• Symbol: Rgs13^tm1.1Jhk
• Name: regulator of G-protein signaling 13; targeted mutation 1.1, John H Kehrl
• MGI ID: MGI:5514157
• Gene: Rgs13 Location: Chr1:144014392-144053110 bp, - strand Genetic Position: Chr1, 62.56 cM
• Alliance: Rgs13^tm1.1Jhk page

Large germinal centers in Rgs13^tm1.1Jhk/Rgs13^tm1.1Jhk mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199530
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: The coding region contained without exon 3 was replaced with EGFP and floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in splenic B cells or Peyer's Patch B. (J:199530)

Construction of the Rgs13^tm1.1Jhk allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs13 Mutation: 15 strains or lines available

References

• Original: J:199530 Hwang IY, et al., Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS One. 2013;8(3):e60139
• All: 1 reference(s)