About   Help   FAQ
Plce1tm2Avsm
Targeted Allele Detail
Summary
Symbol: Plce1tm2Avsm
Name: phospholipase C, epsilon 1; targeted mutation 2, Alan V Smrcka
MGI ID: MGI:5514168
Synonyms: PLCepsilonflox
Gene: Plce1  Location: Chr19:38469557-38773474 bp, + strand  Genetic Position: Chr19, 33.16 cM
Alliance: Plce1tm2Avsm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197247
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 6. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. (J:197247)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plce1 Mutation:  111 strains or lines available
References
Original:  J:197247 Zhang L, et al., Phospholipase Cepsilon hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 2013 Mar 28;153(1):216-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory