Plce1^tm2Avsm
Targeted Allele Detail

Summary

• Symbol: Plce1^tm2Avsm
• Name: phospholipase C, epsilon 1; targeted mutation 2, Alan V Smrcka
• MGI ID: MGI:5514168
• Synonyms: PLCepsilon^flox
• Gene: Plce1 Location: Chr19:38469557-38773474 bp, + strand Genetic Position: Chr19, 33.16 cM
• Alliance: Plce1^tm2Avsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197247
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. (J:197247)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plce1 Mutation: 111 strains or lines available

References

• Original: J:197247 Zhang L, et al., Phospholipase Cepsilon hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 2013 Mar 28;153(1):216-27
• All: 1 reference(s)