Map3k7^tm1Mis
Targeted Allele Detail

Summary

• Symbol: Map3k7^tm1Mis
• Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1, Yuji Mishina
• MGI ID: MGI:5514175
• Synonyms: Tak1^FX
• Gene: Map3k7 Location: Chr4:31964097-32023467 bp, + strand Genetic Position: Chr4, 13.91 cM
• Alliance: Map3k7^tm1Mis page

Mandibular hypoplasia and cleft palate in Map3k7^tm1Mis/Map3k7^tm1MisH2az2^{Tg(Wnt1-cre)11Rth}/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An HPRT cassette with a 3' lox66 site was inserted upstream of exon 2. A lox71 site was inserted downstream of exon 2. Cre-mediated recombination is required to invert exon 2 and inactivate the gene. (J:198588)

Generation of the Map3k7^tm1Mis allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k7 Mutation: 54 strains or lines available

References

• Original: J:198588 Yumoto K, et al., TGF-beta-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem. 2013 May 10;288(19):13467-80
• All: 4 reference(s)