Mmp1atm1Otin
Targeted Allele Detail
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Symbol: |
Mmp1atm1Otin |
Name: |
matrix metallopeptidase 1a (interstitial collagenase); targeted mutation 1, Carlos Lopez-Otin |
MGI ID: |
MGI:5514177 |
Gene: |
Mmp1a Location: Chr9:7464141-7476857 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1-A2
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Alliance: |
Mmp1atm1Otin page
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Phenotypic features of urethane-induced tumors in Mmp1atm1Otin/Mmp1atm1Otin mice
Show the 2 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced part of exon 4 through part of exon 6. Northern blot analysis confirmed the absence of transcript expression in the placenta.
(J:198586)
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Generation of the Mmp1atm1Otin allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mmp1a Mutation: |
41 strains or lines available
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Original: |
J:198586 Fanjul-Fernandez M, et al., Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem. 2013 May 17;288(20):14647-56 |
All: |
4 reference(s) |
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