About   Help   FAQ
Mmp1atm1Otin
Targeted Allele Detail
Summary
Symbol: Mmp1atm1Otin
Name: matrix metallopeptidase 1a (interstitial collagenase); targeted mutation 1, Carlos Lopez-Otin
MGI ID: MGI:5514177
Gene: Mmp1a  Location: Chr9:7464141-7476857 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1-A2
Alliance: Mmp1atm1Otin page
Phenotypic features of urethane-induced tumors in Mmp1atm1Otin/Mmp1atm1Otin mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198586
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 4 through part of exon 6. Northern blot analysis confirmed the absence of transcript expression in the placenta. (J:198586)
Generation of the Mmp1atm1Otin allele
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp1a Mutation:  41 strains or lines available
References
Original:  J:198586 Fanjul-Fernandez M, et al., Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem. 2013 May 17;288(20):14647-56
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory