Spaca6^{Tg(Tyr)Bart97bCeb}
Transgenic Allele Detail

Summary

• Symbol: Spaca6^{Tg(Tyr)Bart97bCeb}
• Name: sperm acrosome associated 6; transgene insertion Bart97b, Colin E Bishop
• MGI ID: MGI:5514186
• Synonyms: Bart97b
• Gene: Spaca6 Location: Chr17:18047420-18063271 bp, + strand Genetic Position: Chr17, 10.5 cM, cytoband A3.1
• Alliance: Spaca6^{Tg(Tyr)Bart97bCeb} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a transgene containing a 4.1kb tyrosinase mini gene under the control of the tyrosinase promoter in line Bart97b produced a 11kb deletion spanning 6 exons (chr17:17,848,861-17,849,039 based on the GRCm38/mm10 assembly). RT-PCR confirmed complete absence of RNA transcripts in homozygous testis. (J:216863)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spaca6 Mutation: 37 strains or lines available

References

• Original: J:216863 Lorenzetti D, et al., A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion. Mamm Genome. 2014 Apr;25(3-4):141-8
• All: 1 reference(s)