Tgfb1^tm3.1Flv
Targeted Allele Detail

Summary

• Symbol: Tgfb1^tm3.1Flv
• Name: transforming growth factor, beta 1; targeted mutation 3.1, Richard A Flavell
• MGI ID: MGI:5514235
• Gene: Tgfb1 Location: Chr7:25386427-25404502 bp, + strand Genetic Position: Chr7, 13.98 cM
• Alliance: Tgfb1^tm3.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196160
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129S1/SvImJ x NOD/ShiLtJ)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette followed by a loxP site was inserted into intron 2. A second loxP site was inserted in intron 1. ES cells targeted to th NOD chromosome were selected. The neo selection cassette was then removed from properly targeted ES cells by flp recombinase expression leaving exon 2 flanked by loxP sites. (J:196160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfb1 Mutation: 35 strains or lines available

Notes

Recombination occurred in ES cells derived from NOD/129 F1 mice

References

• Original: J:196160 Ishigame H, et al., Excessive Th1 responses due to the absence of TGF-beta signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6961-6
• All: 1 reference(s)