Usp2^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Usp2^tm1Dgen
• Name: ubiquitin specific peptidase 2; targeted mutation 1, Deltagen
• MGI ID: MGI:5514236
• Gene: Usp2 Location: Chr9:43978318-44006924 bp, + strand Genetic Position: Chr9, 24.53 cM, cytoband B
• Alliance: Usp2^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance and lacZ gene cassette replaced the last nucleotide of exon 3, all of intron 3 and 4, and the 34 first nucleotides of exon 4. Western blot analysis confirmed the absence of protein expression in the kidney. (J:198755)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp2 Mutation: 34 strains or lines available

References

• Original: J:198755 Pouly D, et al., Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure. Am J Physiol Renal Physiol. 2013 Jul;305(1):F21-30
• All: 2 reference(s)