Cd70^tm1(cre)Jbo
Targeted Allele Detail

Summary

• Symbol: Cd70^tm1(cre)Jbo
• Name: CD70 antigen; targeted mutation 1, Jannie Borst
• MGI ID: MGI:5514249
• Synonyms: Cd70^Cre
• Gene: Cd70 Location: Chr17:57452997-57456777 bp, - strand Genetic Position: Chr17, 29.69 cM, cytoband C-D
• Alliance: Cd70^tm1(cre)Jbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198200
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Cd70^tm1(cre)Jbo expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd70 (MGI:1195273)

• The cre coding sequence replaced exon 1 of the Cd70 locus. This generates a null allele of Cd70. (J:198200)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd70 (mouse) Summary of all recombinase alleles driven by Cd70. Alliance mouse Cd70 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd70 Mutation: 12 strains or lines available

References

• Original: J:198200 Coquet JM, et al., Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J Exp Med. 2013 Apr 8;210(4):715-28
• All: 6 reference(s)