Fktn^tm3.1Ttd
Targeted Allele Detail

Summary

• Symbol: Fktn^tm3.1Ttd
• Name: fukutin; targeted mutation 3.1, Tatsushi Toda
• MGI ID: MGI:5514346
• Synonyms: fukutin^lox
• Gene: Fktn Location: Chr4:53713745-53765785 bp, + strand Genetic Position: Chr4, 28.74 cM
• Alliance: Fktn^tm3.1Ttd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198535
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:198535)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fktn Mutation: 44 strains or lines available

References

• Original: J:198535 Kanagawa M, et al., Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression. Hum Mol Genet. 2013 Aug 1;22(15):3003-15
• All: 5 reference(s)