Sgpl1^tm1.1Npa
Targeted Allele Detail

Summary

• Symbol: Sgpl1^tm1.1Npa
• Name: sphingosine phosphate lyase 1; targeted mutation 1.1, Novartis Pharma AG
• MGI ID: MGI:5514381
• Gene: Sgpl1 Location: Chr10:60934421-60983463 bp, - strand Genetic Position: Chr10, 32.14 cM
• Alliance: Sgpl1^tm1.1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199525
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to use for homologous recombination to flank exon 8 of Sgpl1 with loxP sites b. An frt-neo-frt cassette was also inserted. Chimeric mice were crossed to C57BL/6 mice and then crossed with flp deleter mice to remove the neo. (J:199525)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgpl1 Mutation: 33 strains or lines available

References

• Original: J:199525 Billich A, et al., Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS One. 2013;8(3):e59630
• All: 3 reference(s)