Eif3h^MommeD38
Chemically induced Allele Detail

Summary

• Symbol: Eif3h^MommeD38
• Name: eukaryotic translation initiation factor 3, subunit H; modifier of murine metastable epialleles, D38
• MGI ID: MGI:5514384
• Synonyms: D38
• Gene: Eif3h Location: Chr15:51649956-51728901 bp, - strand Genetic Position: Chr15, 19.42 cM, cytoband D1
• Alliance: Eif3h^MommeD38 page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A transition in exon 7 resulting in a premature stop codon insteam of arginine at position 291 (R291X). QRT-PCR confirmed the reduction in transcript expression in heterozygotes. (J:201509)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif3h Mutation: 32 strains or lines available

References

• Original: J:201509 Daxinger L, et al., A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit H (eIF3h), as an enhancer of variegation in the mouse. G3 (Bethesda). 2012 Nov;2(11):1393-6
• All: 2 reference(s)