Rad50^tm4.1Flv
Targeted Allele Detail

Summary

• Symbol: Rad50^tm4.1Flv
• Name: RAD50 double strand break repair protein; targeted mutation 4.1, Richard A Flavell
• MGI ID: MGI:5514424
• Synonyms: RHS6
• Gene: Rad50 Location: Chr11:53540346-53598146 bp, - strand Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
• Alliance: Rad50^tm4.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196154
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neomycin resistance (neo) cassette replaced DNaseI hypersensitive site 6 (RHS6). Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed normal protein expression. (J:196154)

Generation of the Rad50^tm4.1Flv allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad50 Mutation: 53 strains or lines available

References

• Original: J:196154 Williams A, et al., Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6955-60
• All: 3 reference(s)