Prkar2b^tm3Gsm
Targeted Allele Detail

Summary

• Symbol: Prkar2b^tm3Gsm
• Name: protein kinase, cAMP dependent regulatory, type II beta; targeted mutation 3, G Stanley McKnight
• MGI ID: MGI:5515221
• Gene: Prkar2b Location: Chr12:32008475-32111295 bp, - strand Genetic Position: Chr12, 13.74 cM, cytoband B1
• Alliance: Prkar2b^tm3Gsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance gene and stop signal were inserted in exon 1 about 50 bp upstream of the ATG start codon. Cre excision of the inserted sequence restores gene function. (J:196157)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prkar2b^tm3Gsm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkar2b Mutation: 27 strains or lines available

References

• Original: J:196157 Zheng R, et al., Deficiency of the RIIbeta subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1631-40
• All: 2 reference(s)