Hapln1^{tm1.1(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Hapln1^{tm1.1(KOMP)Mbp}
• Name: hyaluronan and proteoglycan link protein 1; targeted mutation 1.1, Mouse Biology Program, UC Davis
• MGI ID: MGI:5515316
• Gene: Hapln1 Location: Chr13:89688654-89759951 bp, + strand Genetic Position: Chr13, 45.5 cM
• Alliance: Hapln1^{tm1.1(KOMP)Mbp} page
• IMPC: Hapln1 gene page

Mutation origin

• Mutant Cell Line: DEPD00554_4_A03
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 4294 starting at position 89749492 and ending at position 89753786 of Chromosome 13 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Cre-mediated deletion excised the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:157064, J:188991)

Expression

In Mice Carrying this Mutation:

23 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hapln1 Mutation: 28 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 5 reference(s)