Tyrp1^b-Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tyrp1^b-Btlr
• Name: tyrosinase-related protein 1; brown Bruce Beutler
• MGI ID: MGI:5515343
• Synonyms: chi
• Gene: Tyrp1 Location: Chr4:80752360-80769956 bp, + strand Genetic Position: Chr4, 37.89 cM
• Alliance: Tyrp1^b-Btlr page

Brown coat color of the homozygous Tyrp1^b-Btlr mouse

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to G transition at base pair 80840778 (v38) on chromosome 4 in the GenBank genomic region NC_000070 encoding Tyrp1. The mutation corresponds to residue 1159 in the mRNA sequence (NM_031202.2) in exon 4 of 8 total exons. The mutation results in a conversion of tyrosine (Y) to cysteine (C) at residue 296. (J:201717)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyrp1 Mutation: 162 strains or lines available

References

• Original: J:201717 Purrington T, et al., Direct data submission for chi. MGI Direct Data Submission. 2013
• All: 1 reference(s)