Usf1^soc
Allele Detail

Summary

• Symbol: Usf1^soc
• Name: upstream transcription factor 1; suppressor of clock
• MGI ID: MGI:5515410
• Synonyms: Soc^BALB
• Gene: Usf1 Location: Chr1:171238881-171246327 bp, + strand Genetic Position: Chr1, 79.4 cM, cytoband H
• Alliance: Usf1^soc page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Not Applicable
• Mutation: Single point mutation
• Mutation details: A SNP (T in non-suppressor strains, C in suppressor strains) in the promoter results in cis-mediated increase in transcript expression in suppressor strains. Strains A/J, AKR/J, BALBcJ, C3H/HeJ, DBA/2J, FVB/NJ, SJL/J and 129S1/SvlmJ were identified by their ability to suppress the prolonged circadian period observed in Clock^m1Jt heterozygotes compared with C57BL/6, C58/J, BTBR, I/LnJ, MA/MyJ, JF1/Ms, MOLF/EiJ and CZECHII/EiJ. (J:198519)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usf1 Mutation: 81 strains or lines available

References

• Original: J:198519 Shimomura K, et al., Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice. Elife. 2013;2:e00426
• All: 1 reference(s)