Muc19^tm2Culp
Targeted Allele Detail

Summary

• Symbol: Muc19^tm2Culp
• Name: mucin 19; targeted mutation 2, David Culp
• MGI ID: MGI:5515435
• Gene: Muc19 Location: Chr15:91722531-91832440 bp, + strand Genetic Position: Chr15, 46.14 cM, cytoband E3
• Alliance: Muc19^tm2Culp page

Sublingual gland abnormalities in Muc19^tm2Culp/Muc19^tm2Culp, and Muc19^sld/Muc19^sld adults

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199625
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 20 through 25 were replaced with a floxed neomycin resistance/STOP cassette. Western blot analysis confirmed the absence of protein expression in the sublingual gland. (J:199625)

Generation of the Muc19^tm2Culp allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc19 Mutation: 41 strains or lines available

References

• Original: J:199625 Das B, et al., The sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decay. J Biol Chem. 2013 May 24;288(21):14742-55
• All: 1 reference(s)