Mirc14^tm1.1Ankr
Targeted Allele Detail

Summary

• Symbol: Mirc14^tm1.1Ankr
• Name: microRNA cluster 14, including Mir181a-1 through Mir181b-1; targeted mutation 1.1, Andreas Krueger
• MGI ID: MGI:5515722
• Synonyms: miR-181a/b-1^-
• Gene: Mirc14 Location: Chr1:137894193-137894456 bp Genetic Position: Chr1, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196134
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed, self-excising neomycin resistance cassette replaced the coding sequence of Mir181a-1 and Mir181b-1. The neomycin resistance cassette is removed from the final allele. (J:196134)

Generation of the Mirc14^tm1.1Ankr allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc14 Mutation: 1 strain or line available

References

• Original: J:196134 Zietara N, et al., Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7407-12
• All: 5 reference(s)