Dock1^tm2.1Jfco
Targeted Allele Detail

Summary

• Symbol: Dock1^tm2.1Jfco
• Name: dedicator of cytokinesis 1; targeted mutation 2.1, Jean-Francois Cote
• MGI ID: MGI:5515752
• Synonyms: Dock1^flx
• Gene: Dock1 Location: Chr7:134272416-134775376 bp, + strand Genetic Position: Chr7, 79.14 cM
• Alliance: Dock1^tm2.1Jfco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: One loxP site was inserted upstream of exon 1 and a floxed neomycin resistance cassette was inserted downstream. Flp-mediated recombination remove the neomycin resistance cassette and left exon 1 floxed. (J:196659)

Generation of the Dock1^tm2.1Jfco allele

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock1 Mutation: 130 strains or lines available

References

• Original: J:196659 Laurin M, et al., Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7434-9
• All: 4 reference(s)