Tg(Shank3-EGFP)1Hzo
Transgene Detail

Summary

• Symbol: Tg(Shank3-EGFP)1Hzo
• Name: transgene insertion 1, Huda Y Zoghbi
• MGI ID: MGI:5515936
• Synonyms: EGFP-Shank3, Shank3-EGFP
• Transgene: Tg(Shank3-EGFP)1Hzo Location: unknown
• Alliance: Tg(Shank3-EGFP)1Hzo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: Bacterial artificial chromosome RP23-278D8 was modified to contain a Kozak sequence (ACCATGG) followed by enhanced green fluorescent protein (EGFP) sequence at the start codon. Line 1 was generated. Mice carrying this transgene overexpress all 3 of the major Shank3 isoforms. (J:201867)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:201867 Han K, et al., SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013 Nov 7;503(7474):72-7
• All: 12 reference(s)