Rhbdd3^tm1Caox
Targeted Allele Detail

Summary

• Symbol: Rhbdd3^tm1Caox
• Name: rhomboid domain containing 3; targeted mutation 1, Xuetao Cao
• MGI ID: MGI:5516031
• Gene: Rhbdd3 Location: Chr11:5048926-5056093 bp, + strand Genetic Position: Chr11, 3.26 cM
• Alliance: Rhbdd3^tm1Caox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197348
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced the open reading frame. (J:197348)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhbdd3 Mutation: 28 strains or lines available

References

• Original: J:197348 Liu J, et al., Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7814-9
• All: 2 reference(s)