Mrm3^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Mrm3^{tm1.1(KOMP)Vlcg}
• Name: mitochondrial rRNA methyltransferase 3; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5516076
• Synonyms: Mrm3^-
• Gene: Mrm3 Location: Chr11:76134562-76141451 bp, + strand Genetic Position: Chr11, 45.92 cM
• Alliance: Mrm3^{tm1.1(KOMP)Vlcg} page
• IMPC: Mrm3 gene page

Mrm3^{tm1.1(KOMP)Vlcg}/Mrm3^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show embryonic growth retardation and stall in development around E8.0.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 13785A-E7
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 6652bp between positions 76057278-76063929 of Chromosome 11 (Genome Build37), and subsequent Cre-mediated excision deleted the neomycin selection cassette. (J:136110, J:188991)

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mrm3 Mutation: 19 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 6 reference(s)