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Tg(Prnp-ATXN3*70Q)70.61Olri
Transgene Detail
Summary
Symbol: Tg(Prnp-ATXN3*70Q)70.61Olri
Name: transgene insertion 70.61, Olaf Riess
MGI ID: MGI:5516451
Transgene: Tg(Prnp-ATXN3*70Q)70.61Olri  Location: unknown  
Alliance: Tg(Prnp-ATXN3*70Q)70.61Olri page
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-ATXN3*70Q)70.61Olri expresses 1 gene
 
Mutation detailsThe mouse prion promoter (containing 1140 bp of the prion protein gene upstream of exon 1, the complete exon 1, intron 1, and the first 52 bp of exon 2) drives the expression of the full-length human ATAXIN-3 (ATAXIN-3c isoform that contains an additional ubiquitin-interacting motif at its C terminus) containing 70 CAG repeats. Four lines were created: 70.42, 70.48, 70.61, and 70.66. (J:122993)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:122993 Bichelmeier U, et al., Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci. 2007 Jul 11;27(28):7418-28
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory