Tg(Prnp-ATXN3*148Q)NES.24Olri
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATXN3*148Q)NES.24Olri
• Name: transgene insertion NES.24, Olaf Riess
• MGI ID: MGI:5516458
• Transgene: Tg(Prnp-ATXN3*148Q)NES.24Olri Location: unknown
• Alliance: Tg(Prnp-ATXN3*148Q)NES.24Olri page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATXN3*148Q)NES.24Olri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

• Mutation details: The mouse prion promoter (containing 1140 bp of the prion protein gene upstream of exon 1, the complete exon 1, intron 1, and the first 52 bp of exon 2) drives the expression of the full-length human ATAXIN-3 (ATAXIN-3c isoform) containing 148 CAG repeats. To transport ATAXIN-3 into the cytoplasm, the nuclear export signal (NES) of the heat-stable inhibitor of the cAMP-dependent protein kinase was attached to ATAXIN-3. Five lines were created: NES.17, NES.24, NES.34, NES.40 and NES.42. (J:122993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122993 Bichelmeier U, et al., Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci. 2007 Jul 11;27(28):7418-28
• All: 1 reference(s)