Tg(Prnp-ATXN3*148Q)NLS.28Olri
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATXN3*148Q)NLS.28Olri
• Name: transgene insertion NLS.28, Olaf Riess
• MGI ID: MGI:5516462
• Transgene: Tg(Prnp-ATXN3*148Q)NLS.28Olri Location: unknown
• Alliance: Tg(Prnp-ATXN3*148Q)NLS.28Olri page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATXN3*148Q)NLS.28Olri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

• Mutation details: The mouse prion promoter (containing 1140 bp of the prion protein gene upstream of exon 1, the complete exon 1, intron 1, and the first 52 bp of exon 2) drives the expression of the full-length human ATAXIN-3 (ATAXIN-3c isoform) containing 148 CAG repeats. For nuclear targeting of ATAXIN-3, three repeats of the nuclear localization signal from the SV40 T antigen were cloned at the C terminus of ATAXIN-3. Three lines were established: NLS.28, NLS.10, and NLS.37. (J:122993)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122993 Bichelmeier U, et al., Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci. 2007 Jul 11;27(28):7418-28
• All: 2 reference(s)