Npr1^tm1.1Rsha
Targeted Allele Detail

Summary

• Symbol: Npr1^tm1.1Rsha
• Name: natriuretic peptide receptor 1; targeted mutation 1.1, Rameshwar K Sharma
• MGI ID: MGI:5516490
• Synonyms: 669WTAPELL675^-
• Gene: Npr1 Location: Chr3:90357898-90373173 bp, - strand Genetic Position: Chr3, 39.23 cM
• Alliance: Npr1^tm1.1Rsha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201932
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 14 was replaced with a floxed neomycin resistance cassette and a modified exon 14 in which the 669WTAPELL675 motif was deleted. This domain is critical for the transduction of the atrial natriuretic peptide signal. Cre-mediated recombination removed the neomycin resistance cassette. (J:201932)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr1 Mutation: 60 strains or lines available

References

• Original: J:201932 Duda T, et al., The ANF-RGC gene motif (669)WTAPELL(675) is vital for blood pressure regulation: biochemical mechanism. Biochemistry. 2013 Apr 2;52(13):2337-47
• All: 1 reference(s)