Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Rawlings
• MGI ID: MGI:5516595
• Synonyms: Rosa PEP-R619W
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw} page

Renal abnormalities in Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201448
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptpn22 (MGI:107170)

• Mutation details: The construct targeted to the locus contained a floxed STOP cassette, cDNA with the tryptophan for arginine mutation and a N-terminal HA tag, a 2A self-cleaving linker and GFP gene. The mutation is analogous to the human disease-linked variant (LYP-R620W). (J:201448)

Generation of the Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw} allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:201448 Dai X, et al., A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest. 2013 May 1;123(5):2024-36
• All: 2 reference(s)