Nr2c2^tm1Bbm
Targeted Allele Detail

Summary

• Symbol: Nr2c2^tm1Bbm
• Name: nuclear receptor subfamily 2, group C, member 2; targeted mutation 1, Allan Basbaum
• MGI ID: MGI:5517362
• Gene: Nr2c2 Location: Chr6:92068426-92150039 bp, + strand Genetic Position: Chr6, 41.03 cM
• Alliance: Nr2c2^tm1Bbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197895
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. (J:197895)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2c2 Mutation: 67 strains or lines available

References

• Original: J:197895 Wang X, et al., Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron. 2013 Apr 24;78(2):312-24
• All: 3 reference(s)