Tg(CTSG-RARA/ZBTB16)#Sjch
Transgene Detail

Summary

• Symbol: Tg(CTSG-RARA/ZBTB16)#Sjch
• Name: transgene insertion, Sai-Juan Chen
• MGI ID: MGI:5517433
• Synonyms: RARalpha/PLZF
• Transgene: Tg(CTSG-RARA/ZBTB16)#Sjch Location: unknown
• Alliance: Tg(CTSG-RARA/ZBTB16)#Sjch page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CTSG-RARA/ZBTB16)#Sjch expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RARA (5914)

  Rara	(MGI:97856)

  human

  ZBTB16 (7704)

  Zbtb16

  (MGI:103222)

• Mutation details: The human RARA/ZBTB16 fusion gene is under the control of the human cathepsin-G promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:194312)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194312 Jiao B, et al., 8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARalpha degradation. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3495-500
• All: 1 reference(s)