Lmnb1^tm1.2Sgy
Targeted Allele Detail

Summary

• Symbol: Lmnb1^tm1.2Sgy
• Name: lamin B1; targeted mutation 1.2, Stephen G Young
• MGI ID: MGI:5517590
• Gene: Lmnb1 Location: Chr18:56840885-56886496 bp, + strand Genetic Position: Chr18, 30.84 cM
• Alliance: Lmnb1^tm1.2Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197315
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked beta-geo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Subsequent cre expresssion resulted in germline excision of exon 2 and the selection cassette. (J:174963, J:197315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmnb1 Mutation: 39 strains or lines available

References

• Original: J:197315 Jung HJ, et al., Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32
• All: 3 reference(s)