Gnrhr^{tm1(GNRHR1)Xen}
Targeted Allele Detail

Summary

• Symbol: Gnrhr^{tm1(GNRHR1)Xen}
• Name: gonadotropin releasing hormone receptor; targeted mutation 1, Taconic Biosciences
• MGI ID: MGI:5517591
• Synonyms: GNRHR1-Ki
• Gene: Gnrhr Location: Chr5:86328613-86345760 bp, - strand Genetic Position: Chr5, 43.56 cM
• Alliance: Gnrhr^{tm1(GNRHR1)Xen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199193
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The human cDNA and an FRT-flanked neomycin resistance cassette replaced the coding sequence of exon 1 downstream of the translation initiation site. (J:199193)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnrhr Mutation: 20 strains or lines available

References

• Original: J:199193 Tello JA, et al., Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs. Am J Physiol Endocrinol Metab. 2013 Jul;305(1):E67-77
• All: 1 reference(s)