Snca^tm1.1Koks
Targeted Allele Detail

Summary

• Symbol: Snca^tm1.1Koks
• Name: synuclein, alpha; targeted mutation 1.1, Sulev Koks
• MGI ID: MGI:5517595
• Synonyms: SNCA A30P
• Gene: Snca Location: Chr6:60708559-60806839 bp, - strand Genetic Position: Chr6, 29.15 cM
• Alliance: Snca^tm1.1Koks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201391
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 2 was replaced with a modified one in which a point mutation results in the amino acid substitution of proline for alanine at position 30 (A30P), mimicking a mutation found in some Parkinson's disease patients. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted between exon 1a and exon 1b. (J:201391)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snca Mutation: 36 strains or lines available

References

• Original: J:201391 Plaas M, et al., Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. J Physiol Pharmacol. 2008 Jun;59(2):205-16
• All: 3 reference(s)