Pygo2^tm1.1Kba
Targeted Allele Detail

Summary

• Symbol: Pygo2^tm1.1Kba
• Name: pygopus 2; targeted mutation 1.1, Konrad Basler
• MGI ID: MGI:5518423
• Synonyms: Pygo2^A342E
• Gene: Pygo2 Location: Chr3:89337521-89342435 bp, + strand Genetic Position: Chr3, 39.12 cM
• Alliance: Pygo2^tm1.1Kba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198562
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (CC to AG) result in the amino acid substitution of glutamic acid for alanine at position 342 (A342E). Flp-mediated recombination removed an FRT-flanked neomycin resistance cassette inserted upstream of the modified exon. (J:198562)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pygo2 Mutation: 24 strains or lines available

References

• Original: J:198562 Cantu C, et al., The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development. 2013 Jun;140(11):2377-86
• All: 2 reference(s)