Cadm4^{tm1(cre/ERT2)Qiu}
Targeted Allele Detail

Summary

• Symbol: Cadm4^{tm1(cre/ERT2)Qiu}
• Name: cell adhesion molecule 4; targeted mutation 1, Mengsheng Qiu
• MGI ID: MGI:5518469
• Synonyms: Necl-4^-, Necl4-cre
• Gene: Cadm4 Location: Chr7:24181448-24203958 bp, + strand Genetic Position: Chr7, 11.03 cM, cytoband A3-B2
• Alliance: Cadm4^{tm1(cre/ERT2)Qiu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202123
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Cadm4^{tm1(cre/ERT2)Qiu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cadm4 (MGI:2449088)

• Mutation details: A targeting vector composed of the cre/ERT2 sequence and a neo cassette was used to replace exon 1 of the Cadm4 (Necl-4) gene by homologous recombination in ES cells. Two clones were selected for injection to produce chimeras. Germline mutant mice were produced from both clones and these exhibited identical homozygous phenotypes. (J:202123)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cadm4 (mouse) Summary of all recombinase alleles driven by Cadm4. Alliance mouse Cadm4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cadm4 Mutation: 14 strains or lines available

References

• Original: J:202123 Zhu Y, et al., Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination. PLoS One. 2013;8(5):e64264
• All: 2 reference(s)