Gt(ROSA)26Sor^{tm1(Gli2)Jmao}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Gli2)Jmao}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Junhao Mao
• MGI ID: MGI:5518625
• Synonyms: R26^Gli2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Gli2)Jmao} page

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199664
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Gli2)Jmao} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gli2 (MGI:95728)

• Mutation details: The C-terminally FLAG-tagged cDNA preceded by a floxed neomycin resistance and STOP cassette was inserted into the locus. (J:199664)

Generation of the Gt(ROSA)26Sor^{tm1(Gli2)Jmao} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:199664 Huang H, et al., Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14;288(24):17589-96
• All: 1 reference(s)