Sox11^tm1.1Gan
Targeted Allele Detail

Summary

• Symbol: Sox11^tm1.1Gan
• Name: SRY (sex determining region Y)-box 11; targeted mutation 1.1, Lin Gan
• MGI ID: MGI:5518640
• Synonyms: Sox11^loxP
• Gene: Sox11 Location: Chr12:27384263-27392573 bp, - strand Genetic Position: Chr12, 9.95 cM, cytoband A3
• Alliance: Sox11^tm1.1Gan page

Decrease in retinal ganglion cells in single Sox11^tm1.1Gan and Sox4^tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11^tm1.1Gan/Sox11^tm1.1Gan Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0 retinas

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199663
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of the open reading frame. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of the open reading frame. Flp-mediated recombination removed the neomycin resistance cassette and left the open reading frame floxed. (J:199663)

Generation of the Sox11^tm1.1Gan allele

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox11 Mutation: 15 strains or lines available

References

• Original: J:199663 Jiang Y, et al., Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013 Jun 21;288(25):18429-38
• All: 3 reference(s)