Il7^tm1.1Mysl
Targeted Allele Detail

Summary

• Symbol: Il7^tm1.1Mysl
• Name: interleukin 7; targeted mutation 1.1, Myeong Sup Lee
• MGI ID: MGI:5518726
• Synonyms: Il7^eGFP
• Gene: Il7 Location: Chr3:7637088-7678820 bp, - strand Genetic Position: Chr3, 2.02 cM
• Alliance: Il7^tm1.1Mysl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200544
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An EGFP with a polyadenylation sequence and floxed neomycin resistance cassette replaced 191 bp of the 5' untranslated region (247 bp in full length), leaving 56 bp of 5' end part of IL-7 5' untranslated region. Cre-mediated recombination removed the neomycin resistance cassette. (J:200544)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il7 Mutation: 33 strains or lines available

References

• Original: J:200544 Miller CN, et al., IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug;25(8):471-83
• All: 6 reference(s)