Cavin3^tm1Pemi
Targeted Allele Detail

Summary

• Symbol: Cavin3^tm1Pemi
• Name: caveolae associated 3; targeted mutation 1, Peter Michaely
• MGI ID: MGI:5518819
• Synonyms: Cavin-3 KO, Prkcdbp^-
• Gene: Cavin3 Location: Chr7:105129823-105131404 bp, - strand Genetic Position: Chr7, 55.87 cM, cytoband F1
• Alliance: Cavin3^tm1Pemi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202374
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a loxP-flanked NEO cassette was used to disrupt exon 1 and most of exon 2. No gene product (protein) is detected by Western blot analysis of MEFs isolated from homozygous animals. (J:202374)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cavin3 Mutation: 11 strains or lines available

References

• Original: J:202374 Hernandez VJ, et al., Cavin-3 dictates the balance between ERK and Akt signaling. Elife. 2013;2:e00905
• All: 2 reference(s)