Tg(Hoxa5-cre)444CLjea
Transgene Detail

Summary

• Symbol: Tg(Hoxa5-cre)444CLjea
• Name: transgene insertion 444C, Lucie Jeannotte
• MGI ID: MGI:5518946
• Synonyms: Tg(7.1kb Hoxa5-cre)Ljea
• Transgene: Tg(Hoxa5-cre)444CLjea Location: unknown
• Alliance: Tg(Hoxa5-cre)444CLjea page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Hoxa5-cre)444CLjea expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Hoxa5

• Mutation details: A 5 kb genomic fragment of Hoxa5 (containing the temporal (T) control region, the brachial spinal cord (BSC) enhancer, proximal Hoxa5 promoter, both exons and the intron of Hoxa5) drives cre epxression in this transgene. An IRES-EGFPcre cassette was inserted into exon 1 of Hoxa5 downstream of the translation initiation codon. A 2.1 kb fragment containing the mesodermal (MES) enhancer was added at the 3' end of the construct to produce the 7.1 Hoxa5/Cre transgene. Nine founder lines were obtained andLine 444C was established. This line has 2 copies of the transgene. (J:207917)

Generation of Tg(Hoxa5-cre)444CLjea.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxa5 (species not specified) Summary of all recombinase alleles driven by Hoxa5. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:207917 Berube-Simard FA, et al., Hoxa5/Cre transgenic mice: novel tools for regional deletion along the anterior-posterior axis. Genesis. 2014 Feb;52(2):149-56
• All: 2 reference(s)