Del(16Hspa13-App)3Yah
Targeted Allele Detail

Summary

• Symbol: Del(16Hspa13-App)3Yah
• Name: deletion, Chr 16, Yann Herault 3
• MGI ID: MGI:5519049
• Synonyms: Del(16Hspa13-App)Ms3Yah, Del(Stch-App), Del (Stch-App)Ms3Yah, Ms3Yah
• Gene: Del(16Hspa13-App)3Yah Location: Chr16:75552078-84970840 bp Genetic Position: Chr16, Syntenic

Skeletal muscle abnormalities in Del(16Hspa13-App)3Yah/+ and Dp(16Hspa13-App)2Yah/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202375
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Intergenic deletion, Intragenic deletion Del(16Hspa13-App)3Yah involves 80 genes/genome features (Gm11146, Gm22923, Gm21833 ...) View all Mutation details: Chr 16 contains a ~10.0 Mb deletion generated in ES cells by Cre-mediated recombination between loxP sites that had been introduced into Hspa13 (formerly Stch) and App by homologous recombination using targeting vectors from the Mutagenic Insertion and Chromosome Engineering Resource (MICER). (J:82809)

Generation of the Del(16Hspa13-App)3Yah deletion and Dp(16Hspa13-App)2Yah duplication

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(16Hspa13-App)3Yah Mutation: 1 strain or line available

Notes

Phenotypic Similarity to Human Syndrome: Monosomy 21 J:223518

References

• Original: J:202375 Herault Y, et al., Tackling the complexity of the genotype-phenotype relationship in the Down syndrome with the mouse aneuploidy zoo: a resource of new models to study aneuploidies involving human chromosome 21. 2009;:Abstr
• All: 3 reference(s)