Tg(Pkd1*)39Mtru
Transgene Detail

Summary

• Symbol: Tg(Pkd1*)39Mtru
• Name: transgene insertion 39, Marie Trudel
• MGI ID: MGI:5519083
• Synonyms: Pkd1-extra
• Transgene: Tg(Pkd1*)39Mtru Location: unknown
• Alliance: Tg(Pkd1*)39Mtru page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pkd1*)39Mtru expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pkd1 (MGI:97603)

• Mutation details: A BAC was modified to truncate murine Pkd1 such that the region just prior to the first transmembrane and the membrane-spanning and intracellular domains is deleted and produces only the extracellular domain. A second modification removed the Tsc2 gene from the BAC. Immunoblotting confirmed protein expression in various tissues including kidney, brain, liver, lung, and spleen. Four lines were generated (2, 9, 11, and 39) with 2 to 85 copies of the transgene. All lines show a similar phenotype. Line 39 is the low expressing line with 2 copies of the transgene. (J:198147)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:198147 Kurbegovic A, et al., Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain. Hum Mol Genet. 2013 Jun 15;22(12):2361-75
• All: 3 reference(s)