Arid5a^tm1Rnis
Targeted Allele Detail

Summary

• Symbol: Arid5a^tm1Rnis
• Name: AT-rich interaction domain 5A; targeted mutation 1, Riko Nishimura
• MGI ID: MGI:5519212
• Gene: Arid5a Location: Chr1:36346814-36363110 bp, + strand Genetic Position: Chr1, 15.2 cM
• Alliance: Arid5a^tm1Rnis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197418
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion A floxed neomycin selection cassette replaced the major part of the DNA binding domain. (J:197418)

Generation of the Arid5a^tm1Rnis allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arid5a Mutation: 33 strains or lines available

References

• Original: J:197418 Masuda K, et al., Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9409-14
• All: 6 reference(s)