Edn2^tm1Ywa
Targeted Allele Detail

Summary

• Symbol: Edn2^tm1Ywa
• Name: endothelin 2; targeted mutation 1, Masashi Yanagisawa
• MGI ID: MGI:5519239
• Synonyms: Edn2KO
• Gene: Edn2 Location: Chr4:120018403-120024557 bp, + strand Genetic Position: Chr4, 55.77 cM
• Alliance: Edn2^tm1Ywa page

Decreased body weight in Edn2^tm1Ywa/Edn2^tm1Ywa mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201436
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced part of exon 1 and all of exon 2. RT-PCR confirmed the absence of transcript expression in the stomach, small intestine and colon. (J:201436)

Generation of the Edn2^tm1Ywa allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Edn2 Mutation: 14 strains or lines available

References

• Original: J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
• All: 3 reference(s)