Bscl2^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Bscl2^tm1Geno
• Name: BSCL2 lipid droplet biogenesis associated, seipin; targeted mutation 1, Genoway
• MGI ID: MGI:5519934
• Gene: Bscl2 Location: Chr19:8814831-8826047 bp, + strand Genetic Position: Chr19, 5.76 cM
• Alliance: Bscl2^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200947
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 4 through 6 were replaced with a neomycin resistance cassette. (J:200947)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bscl2 Mutation: 36 strains or lines available

References

• Original: J:200947 Prieur X, et al., Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice. Diabetologia. 2013 Aug;56(8):1813-25
• All: 5 reference(s)