Lin28a^tm1.2Gqda
Targeted Allele Detail

Summary

• Symbol: Lin28a^tm1.2Gqda
• Name: lin-28 homolog A; targeted mutation 1.2, George Q Daley
• MGI ID: MGI:5519953
• Gene: Lin28a Location: Chr4:133730641-133746152 bp, - strand Genetic Position: Chr4, 66.5 cM
• Alliance: Lin28a^tm1.2Gqda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177113
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 via homologous recombination. FLP-mediated recombination removed the neomycin cassette. (J:101977, J:177113)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lin28a Mutation: 76 strains or lines available

References

• Original: J:177113 Zhu H, et al., The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell. 2011 Sep 30;147(1):81-94
• All: 11 reference(s)