Pcdh17^tm1.1Sia
Targeted Allele Detail

Summary

• Symbol: Pcdh17^tm1.1Sia
• Name: protocadherin 17; targeted mutation 1.1, Shinichi Aizawa
• MGI ID: MGI:5520081
• Gene: Pcdh17 Location: Chr14:84680626-84775005 bp, + strand Genetic Position: Chr14, 43.54 cM
• Alliance: Pcdh17^tm1.1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201552
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding a part of the extracellular cadherin domain exon 1 was replaced with a lox71 site, lacZ gene, polyadenylation sequence, FRT site, neomycin resistance cassette, FRT site, loxP site and polyadenylation sequence. Cre-mediated recombination removed the lacZ and neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the anterior and posteror striatum. (J:201552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdh17 Mutation: 53 strains or lines available

References

• Original: J:201552 Hoshina N, et al., Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits. Neuron. 2013 Jun 5;78(5):839-54
• All: 1 reference(s)