Mmp14^tm1Stjw
Targeted Allele Detail

Summary

• Symbol: Mmp14^tm1Stjw
• Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Stephen Weiss
• MGI ID: MGI:5520085
• Synonyms: Mmp14^f
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^tm1Stjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. (J:198679)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 44 strains or lines available

References

• Original: J:198679 Tang Y, et al., MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28;25(4):402-16
• All: 4 reference(s)