Ascl3^{tm1.1(EGFP/cre)Ovi}
Targeted Allele Detail

Summary

• Symbol: Ascl3^{tm1.1(EGFP/cre)Ovi}
• Name: achaete-scute family bHLH transcription factor 3; targeted mutation 1.1, Catherine E Ovitt
• MGI ID: MGI:5520171
• Gene: Ascl3 Location: Chr7:109326672-109330933 bp, - strand Genetic Position: Chr7, 57.46 cM
• Alliance: Ascl3^{tm1.1(EGFP/cre)Ovi} page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:139151
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase, Reporter)
• Mutations: Insertion, Intragenic deletion
• Ascl3^{tm1.1(EGFP/cre)Ovi} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ascl3 (MGI:1928820)

• Mutation details: A targeting vector was constructed to insert an EGFP-Cre recombinase fusion expression cassette with a 3' beta-globin polyadenylation site and loxP-flanked PGK-neomycin cassette into exon 2, replacing the entire coding sequence. Cre-mediated recombination removed the neomycin cassette. (J:101977, J:139151)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ascl3 (mouse) Summary of all recombinase alleles driven by Ascl3. Alliance mouse Ascl3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ascl3 Mutation: 9 strains or lines available

References

• Original: J:139151 Bullard T, et al., Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands. Dev Biol. 2008 Aug 1;320(1):72-8
• All: 3 reference(s)