Sema3d^tm1.1Joe
Targeted Allele Detail

Summary

• Symbol: Sema3d^tm1.1Joe
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; targeted mutation 1.1, Jonthan Epstein
• MGI ID: MGI:5520920
• Gene: Sema3d Location: Chr5:12433352-12638915 bp, + strand Genetic Position: Chr5, 3.97 cM, cytoband A2
• Alliance: Sema3d^tm1.1Joe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198676
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A stop cassette and an FRT-flanked neomycin resistance cassette replaced most of exon 2 and the splice donor site. Flp-mediated recombination removed the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expresion in the heart, brain and lung. (J:198676)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema3d Mutation: 53 strains or lines available

References

• Original: J:198676 Degenhardt K, et al., Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections. Nat Med. 2013 Jun;19(6):760-5
• All: 1 reference(s)